Two sample MR report
HP_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 13 | -0.1460554 | 0.0928852 | 0.1441525 |
| Weighted median | 13 | -0.0382066 | 0.0156042 | 0.0143457 |
| Inverse variance weighted | 13 | -0.0313478 | 0.0119148 | 0.0085134 |
| Simple mode | 13 | -0.0393475 | 0.0228113 | 0.1101800 |
| Weighted mode | 13 | -0.0415183 | 0.0239205 | 0.1082007 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.359701 | 11 | 0.9850678 |
| Inverse variance weighted | 4.910291 | 12 | 0.9609083 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0936109 | 0.0751758 | 0.238922 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004044 | 0 | TRUE | 0.0559725 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
